Detailed view for Bm1_21560

Basic information

TDR Targets ID: 238243
Brugia malayi, double-strand break repair protein mre-11
Source Database / ID:  GenBank

pI: 6.6111 | Length (AA): 1338 | MW (Da): 151347 | Paralog Number: 0

Signal peptide: N | GPI Anchor: | Predicted trans-membrane segments: 0

Druggability Group : DG2

Targets have been classified into druggability groups (DG) according to their druggability score in network driven prioritizations. DGs range from 1 to 5; the higher the group number, the higher the chance of the target to be druggable

Pfam domains

PF00149   Calcineurin-like phosphoesterase
PF04152   Mre11 DNA-binding presumed domain
PF17120   Zinc-ribbon, C4HC2 type

Gene Ontology

Mouse over links to read term descriptions.
GO:0030870   Mre11 complex  
GO:0005634   nucleus  
GO:0004527   exonuclease activity  
GO:0004519   endonuclease activity  
GO:0030145   manganese ion binding  
GO:0016787   hydrolase activity  
GO:0008408   3'-5' exonuclease activity  
GO:0005515   protein binding  
GO:0006302   double-strand break repair  
GO:0006259   DNA metabolic process  

Structural information

Modbase 3D models:

There are 9 models calculated for this protein. More info on these models, including the models themselves is available at: Modbase

Target Beg Target End Template Template Beg Template End Identity Evalue Model Score MPQS zDope
9 423 4fbk (B) 488 1413 41.00 0 1 0.753764 -0.57
18 417 3t1i (A) 8 396 47.00 0 1 0.816554 -0.71
23 121 2q8u (A) 7 115 30.00 0.018 1 0.528791 -1.24
448 888 2j04 (B) 168 675 13.00 0 0.99 0.253196 0.97
480 841 2xyi (A) 13 409 16.00 0 1 0.317153 0.91
480 841 4pbz (A) 5 405 16.00 0 0.93 0.347153 0.6
632 698 2aq5 (A) 87 160 36.00 0.28 0.92 0.328875 0.34
636 788 4lg8 (A) 273 419 24.00 0.03 0.99 0.38515 -0.21
666 928 3sfz (A) 612 875 24.00 0.053 1 0.417362 0.2

Help me make sense of these data.

Target Beg: first modeled residue
Target End: last modeled residue
Template: template structure used for modelling (PDB accession and chain)
Template Beg: first template residue in target-template alignment
Template End: last template residue in target-template alignment
Identity: sequence identity
Evalue: E value for target-template hit
Model Score: GA341 score (>0.7 for reliable model)
MPQS: ModPipe Quality Score (>1.1 for reliable model)
zDope: zDope Score (negative for reliable model)

A more detailed description of these scores is available at the Modbase Model Evaluation Help Pages, and in the papers referenced therein.

PDB Structures:

No structure availble in the PDB for this protein

Expression

No expression data available for this gene

Orthologs

Ortholog group members (OG5_127969)

Species Accession Gene Product
Arabidopsis thaliana AT5G54260   double-strand break repair protein MRE11
Babesia bovis BBOV_III007250   DNA repair protein (mre11) family protein
Brugia malayi Bm1_21560   double-strand break repair protein mre-11
Candida albicans CaO19_6915   hypothetical protein
Candida albicans CaO19.6915   meiotic recombination complex
Caenorhabditis elegans CELE_ZC302.1   Protein MRE-11
Cryptosporidium hominis Chro.10164   DNA repair and meiosis protein Mre11 (emb
Cryptosporidium parvum cgd1_1420   DNA repair and meiosis protein Mre11 (emb
Dictyostelium discoideum DDB_G0293546   3'-5' exonuclease
Drosophila melanogaster Dmel_CG16928   meiotic recombination 11
Echinococcus granulosus EgrG_000145400   double strand break repair protein MRE11A
Entamoeba histolytica EHI_125910   double-strand break repair protein MRE11, putative
Echinococcus multilocularis EmuJ_000145400   double strand break repair protein MRE11A
Echinococcus multilocularis EmuJ_000139050   double strand break repair protein MRE11A
Giardia lamblia GL50803_14493   Mre11, putative
Homo sapiens ENSG00000020922   MRE11 meiotic recombination 11 homolog A (S. cerevisiae)
Leishmania braziliensis LbrM.27.2030   endo/exonuclease Mre11, putative
Leishmania donovani LdBPK_271790.1   endo/exonuclease Mre11, putative
Leishmania infantum LinJ.27.1790   endo/exonuclease Mre11, putative
Leishmania major LmjF.27.1890   endo/exonuclease Mre11, putative
Leishmania mexicana LmxM.27.1890   endo/exonuclease Mre11, putative
Loa Loa (eye worm) LOAG_00022   hypothetical protein
Mus musculus ENSMUSG00000031928   meiotic recombination 11 homolog A (S. cerevisiae)
Neospora caninum NCLIV_067970   double-strand break repair protein, putative
Oryza sativa 4337137   Os04g0635900
Plasmodium berghei PBANKA_0205600   double-strand break repair protein MRE11, putative
Plasmodium falciparum PF3D7_0107800   double-strand break repair protein MRE11
Plasmodium knowlesi PKNH_0205800   double-strand break repair protein MRE11, putative
Plasmodium vivax PVX_081385   double-strand break repair protein MRE11, putative
Plasmodium yoelii PY06177   rad32-related
Saccharomyces cerevisiae YMR224C   Mre11p
Schistosoma japonicum Sjp_0069970   Double-strand break repair protein MRE11A, putative
Schistosoma mansoni Smp_068110   meiotic recombination repair protein 11 (mre11)
Schmidtea mediterranea mk4.014816.00   Mre11-like protein
Schmidtea mediterranea mk4.006709.01   Double-strand break repair protein MRE11A
Trypanosoma brucei gambiense Tbg.972.2.2460   endo/exonuclease Mre11, putative
Trypanosoma brucei Tb927.2.4390   endo/exonuclease Mre11
Trypanosoma congolense TcIL3000_2_790   endo/exonuclease Mre11, putative
Trypanosoma cruzi TcCLB.509099.70   endo/exonuclease Mre11, putative
Trypanosoma cruzi TcCLB.509319.60   endo/exonuclease Mre11, putative
Toxoplasma gondii TGME49_278060   Mre11 DNA-binding domain-containing protein
Theileria parva TP04_0621   DNA repair exonuclease, putative
Trichomonas vaginalis TVAG_098295   nuclease Mre11

Essentiality

Bm1_21560 has one or more orthologs with essentiality data
Gene/Ortholog Organism Phenotype Source Study
Tb927.2.4390 Trypanosoma brucei no significant loss or gain of fitness in bloodstream forms (3 days) alsford
Tb927.2.4390 Trypanosoma brucei no significant loss or gain of fitness in bloodstream forms (6 days) alsford
Tb927.2.4390 Trypanosoma brucei no significant loss or gain of fitness in procyclic forms alsford
Tb927.2.4390 Trypanosoma brucei no significant loss or gain of fitness in differentiation of procyclic to bloodstream forms alsford
CELE_ZC302.1 Caenorhabditis elegans embryonic lethal wormbase
TGME49_278060 Toxoplasma gondii Essentiality uncertain sidik
Show/Hide essentiality data references
  • alsford High-throughput phenotyping using parallel sequencing of RNA interference targets in the African trypanosome Genome Res 2011, 21:915-924
  • gerdes Experimental determination and system-level analysis of essential genes in E. coli MG1655 Gerdes et al., J Bacteriol. 2003 185:5673-84
  • goodall The Essential Genome of Escherichia coli K-12 (Transposon directed high-throughput mutagenesis) Goodall, Emily CA, et al. "The essential genome of Escherichia coli K-12." mBio 9.1 (2018): e02096-17.
  • neb C. elegans RNAi phenotypes Data obtained from Wormbase WS150, curated by K. Chaudary and T. Carlow, New England Biolabs
  • wormbase C. elegans RNAi experiments WormBase web site, http://www.wormbase.org, release WS170
  • plasmo Functional Profiling of a Plasmodium Genome Reveals an Abundance of Essential Genes. Bushell, Ellen, et al. "Functional profiling of a Plasmodium genome reveals an abundance of essential genes." Cell 170.2 (2017): 260-272.
  • blattner Systematic mutagenesis of the E. coli (MG1655) genome J Bacteriol 2004, 186:4921-4930
  • shigen Profiling of E. coli Chromosome (PEC) National Institute of Genetics, Japan
  • keio Systematic single-gene knock-out mutants of E. coli K12 The Keio Collection
  • sidik A Genome-wide CRISPR Screen in Toxoplasma Identifies Essential Apicomplexan Genes. Sidik, Saima M., et al. "A genome-wide CRISPR screen in toxoplasma identifies essential apicomplexan genes." Cell 166.6 (2016): 1423-1435.
  • yeastgenome Systematic deletion of yeast genes Saccharomyces Genome Database
  • nmpdr Genome-scale essentiality datasets from published studies (M. tuberculosis) National Microbial Pathogen Data Resource

Phenotypes and Validation (curated)

We have no manually annotated phenotypes for this target. What does this mean? / Care to help?

In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.

In any case, if you have information about papers containing relevant validation data for this target, please contact us.

Annotated validation

No validation data for this target

Associated compounds / Druggability

Known modulators for this target

No chemical compounds associated to this gene

Predicted associations

By orthology with druggable targets
Species Known druggable target Linked compounds Reference
Homo sapiens MRE11 meiotic recombination 11 homolog A (S. cerevisiae) Compounds References
By sequence similarity to non orthologous druggable targets
No additional associated druggable targets
Obtained from network model
No druggable targets predicted through repurposing network model

Assayability

Assay information

No assay information for this target.

Reagent availability

No reagent availability information for this target.

Bibliographic References

No literature references available for this target.

If you have references for this gene, please enter them in a user comment (below) or Contact us.

User comments

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Gene identifier Bm1_21560 (Brugia malayi), double-strand break repair protein mre-11
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